2-(4-Chlorobenzoyl)benzoic Acid: The Chemical Cornerstone for Medicinal and Dye Synthesis

Introduction:

2-(4-Chlorobenzoyl)benzoic acid, often abbreviated as CBB and identified by the CAS number 85-56-3, stands as a pivotal compound in the synthesis of pharmaceuticals and dyes. This article explores its chemical profile, physical characteristics, applications, and safety considerations in various industrial processes.

Chemical Profile:

CBB boasts a molecular formula of C14H9ClO3, with a molar mass of 260.67 g/mol and a predicted density of 1.357±0.06 g/cm³. It crystallizes with a melting point of 149-150 °C (lit.) and a predicted boiling point of 470.8±30.0 °C. Its flash point is recorded at 238.5°C, indicating its potential for ignitable vapor formation in air.

Physical Characteristics:

Typically appearing as crystalline solids, CBB exhibits a color range from white to off-white, reflecting its purity and quality as a reagent.

Storage and Safety:

For optimal stability, CBB should be stored in a sealed container in a dry environment at room temperature. Due to its potential as an irritant, caution must be exercised when handling this compound, and appropriate protective measures should be implemented.

Applications:

CBB finds extensive applications as an intermediate in pharmaceutical and dye synthesis:

• Pharmaceuticals: It serves as a key building block in the synthesis of chlorthalidone, a diuretic used in the treatment of hypertension.

• Dyes and Pigments: CBB acts as a precursor in the production of 2-chloroanthraquinone, a vital component in the manufacturing of various anthraquinone dyes.

Conclusion:

In conclusion, 2-(4-Chlorobenzoyl)benzoic acid plays an indispensable role in both pharmaceutical and dye industries. Its significance as a chemical intermediate underscores its value in the synthesis of complex molecules, contributing to advancements in medicinal and dye chemistry. Adherence to proper handling and safety protocols ensures its effective utilization in diverse industrial processes while maintaining workplace safety standards.