2-Chloroacetamide: A Versatile Intermediate in Organic Synthesis

Introduction

2-Chloroacetamide, known by various synonyms such as KM 101, Mergal AF, and NSC 8408, is a crucial compound in organic synthesis. Identified by the CAS number 79-07-2, it is widely used in the production of various organic compounds and pharmaceutical intermediates.

Chemical Profile

• Molecular Formula: C2H4ClNOC_2H_4ClNOC2H4ClNO

• Molar Mass: 93.51 g/mol

• Density: 0.84 g/cm³

• Melting Point: 116-118°C (lit.)

• Boiling Point: 224.5°C

• Flash Point: 170°C

Physical Properties

2-Chloroacetamide appears as white crystals and is soluble in water (90 g/L) and in absolute ethanol (10 times its volume). It is very slightly soluble in ether, making it versatile for various chemical reactions.

Applications

This compound is primarily used for:

• Synthesis of Chloroacetonitrile: A crucial step in various organic synthesis pathways.

• Production of Pharmaceutical Intermediates: Such as sulfamethoxazole pyrazine.

• Organic Synthesis: Serving as a building block for numerous compounds.

Storage and Safety

2-Chloroacetamide should be stored below +30°C in a cool, ventilated, and dry place. It must be kept separate from food raw materials to prevent contamination. As an irritant and corrosive substance, it can stimulate the skin and mucous membranes. Proper protective equipment, such as gloves and goggles, should be worn when handling it.

Conclusion

2-Chloroacetamide is an essential intermediate in the chemical industry, facilitating the synthesis of important pharmaceuticals and organic compounds. Its versatility and reactivity make it a valuable asset in various industrial applications.