Alpha-Ketoglutaric acid (CAS: 328-50-7) is an important organic compound, playing a key role in metabolism as a vital intermediate in the tricarboxylic acid (TCA) cycle. It is a key substance in nitrogen transport and molecular oxidation processes. This compound is not only a crucial metabolic intermediate but also a precursor for the synthesis of several amino acids and proteins, which are essential for cell growth and repair.
This compound, also known as 2-Oxoglutaric acid, is commonly found in sports nutrition products due to its metabolic benefits. It supports energy production and enhances athletic performance. In addition to its use in nutrition, Alpha-Ketoglutaric acid is an essential reagent in scientific research for amino acid conversion and enzyme studies.
Alpha-Ketoglutaric acid appears as a white crystalline powder, which can turn light gray-yellow with prolonged storage. It has a molecular formula of C5H6O5 and a molecular weight of 146.1 g/mol. It has excellent stability under controlled storage conditions, making it a valuable addition to both pharmaceutical and health product formulations.
| Product Name | Alpha-Ketoglutaric acid |
| Synonyms | 2-Oxoglutaric acid; 2-Oxopentanedioic acid; 2-Ketoglutaric acid; alpha-Ketoglutaric Acid; A-KETOGLUTARIC ACID; GAMMA-KETOGLUTARIC ACID; FEMA 3891; KETO-GLU; PENTANEDIOIC ACID, 2-OXO-; 2-Oxo-1,5-dipentanedioic acid; 2-Oxo-1,5-pentanedioic acid; 2-oxo-pentanedioicaci; 2-Oxpentanedioicacid; Glutaric acid, 2-oxo-; Glutaric acid, alpha keto; -Ketoglutaricacid; α-Ketoglutaricacid; A-KETOGLUTARIC ACID FREE ACID CELL*CULTU RE TESTED; A-KETOGLUTARIC ACID FREE ACID; 2-KETOGLUTARIC ACID BIOSYNTH |
| Molecular Formula | C5H6O5 |
| Molecular Weight | 146.1 |
| CAS Registry Number | 328-50-7 |
| Molecular Structure |  |
| Product Application | Mainly as a component of sports nutrition drinks |
Supports Metabolism: Plays a key role in the Krebs cycle, enhancing cellular energy production.
Athletic Performance: Commonly used in sports nutrition drinks to support physical endurance and muscle recovery.
Versatile Applications: Used in organic synthesis, as a reagent in enzyme determination, and in liver function tests.
Health Supplement: Serves as a raw material for the development of medicines and health products, supporting overall well-being.
Solubility: Slightly soluble in water, enhancing its role in biological systems.
Stability: Stable under standard storage conditions but may change color over time.
Reactivity: Reacts with water and can be harmful to the environment if mishandled.
Melting Point: 113–115°C, ideal for storage in controlled temperatures.
Density: 1.54 g/cm³, ensuring its stable presence in nutritional and chemical formulations.
Enzyme Activity Determination: Alpha-Ketoglutaric acid serves as a substrate for the determination of amino-converting enzymes and dehydrogenase. It is also used as a supporting reagent in liver function tests, helping to assess metabolic processes.
Sports Nutrition: A key ingredient in sports nutrition drinks, Alpha-Ketoglutaric acid supports enhanced physical performance by aiding in energy production and muscle recovery, making it an essential component for athletes.
Health and Medicine: Used as a raw material and food additive in the formulation of medicines and health products, it contributes to overall well-being by playing a vital role in metabolic processes and amino acid synthesis.
Analytical Applications: Employed as an analytical reagent for tryptophan, Alpha-Ketoglutaric acid is essential in enzyme activity studies. It is particularly valuable as a substrate for determining amino-converting enzyme and dehydrogenase levels in laboratory tests.
Organic Synthesis: As a derivative of valeric acid, Alpha-Ketoglutaric acid is a critical intermediate product in the Krebs cycle, catalyzed by glutamate dehydrogenase. This makes it an important building block in the synthesis of other organic compounds used in various industrial applications.
Environmental Impact: Handle with care to avoid contact with water, as it may be harmful to the environment.
Storage Conditions: Store between 2–8°C to maintain its quality and stability.
Safety Precautions: Follow standard laboratory and manufacturing safety guidelines when handling this compound.
What is Alpha-Ketoglutaric acid used for?
Alpha-Ketoglutaric acid is primarily used in sports nutrition, organic synthesis, and as a reagent in enzyme activity studies.
Is Alpha-Ketoglutaric acid soluble in water?
It is slightly soluble in water, allowing it to participate effectively in biological and metabolic processes.
How should Alpha-Ketoglutaric acid be stored?
It should be stored at temperatures between 2–8°C to ensure optimal quality.
What are the benefits of using Alpha-Ketoglutaric acid in sports nutrition?
It helps in enhancing energy production, supporting muscle recovery, and improving athletic performance.
Is Alpha-Ketoglutaric acid safe to use in food and health products?
Yes, when used within regulated guidelines, it is safe for inclusion in nutritional supplements and health products.
Alpha-Ketoglutaric acid (CAS: 328-50-7) is an important organic compound, playing a key role in metabolism as a vital intermediate in the tricarboxylic acid (TCA) cycle. It is a key substance in nitrogen transport and molecular oxidation processes. This compound is not only a crucial metabolic intermediate but also a precursor for the synthesis of several amino acids and proteins, which are essential for cell growth and repair.
This compound, also known as 2-Oxoglutaric acid, is commonly found in sports nutrition products due to its metabolic benefits. It supports energy production and enhances athletic performance. In addition to its use in nutrition, Alpha-Ketoglutaric acid is an essential reagent in scientific research for amino acid conversion and enzyme studies.
Alpha-Ketoglutaric acid appears as a white crystalline powder, which can turn light gray-yellow with prolonged storage. It has a molecular formula of C5H6O5 and a molecular weight of 146.1 g/mol. It has excellent stability under controlled storage conditions, making it a valuable addition to both pharmaceutical and health product formulations.
| Product Name | Alpha-Ketoglutaric acid |
| Synonyms | 2-Oxoglutaric acid; 2-Oxopentanedioic acid; 2-Ketoglutaric acid; alpha-Ketoglutaric Acid; A-KETOGLUTARIC ACID; GAMMA-KETOGLUTARIC ACID; FEMA 3891; KETO-GLU; PENTANEDIOIC ACID, 2-OXO-; 2-Oxo-1,5-dipentanedioic acid; 2-Oxo-1,5-pentanedioic acid; 2-oxo-pentanedioicaci; 2-Oxpentanedioicacid; Glutaric acid, 2-oxo-; Glutaric acid, alpha keto; -Ketoglutaricacid; α-Ketoglutaricacid; A-KETOGLUTARIC ACID FREE ACID CELL*CULTU RE TESTED; A-KETOGLUTARIC ACID FREE ACID; 2-KETOGLUTARIC ACID BIOSYNTH |
| Molecular Formula | C5H6O5 |
| Molecular Weight | 146.1 |
| CAS Registry Number | 328-50-7 |
| Molecular Structure | |
| Product Application | Mainly as a component of sports nutrition drinks |
Supports Metabolism: Plays a key role in the Krebs cycle, enhancing cellular energy production.
Athletic Performance: Commonly used in sports nutrition drinks to support physical endurance and muscle recovery.
Versatile Applications: Used in organic synthesis, as a reagent in enzyme determination, and in liver function tests.
Health Supplement: Serves as a raw material for the development of medicines and health products, supporting overall well-being.
Solubility: Slightly soluble in water, enhancing its role in biological systems.
Stability: Stable under standard storage conditions but may change color over time.
Reactivity: Reacts with water and can be harmful to the environment if mishandled.
Melting Point: 113–115°C, ideal for storage in controlled temperatures.
Density: 1.54 g/cm³, ensuring its stable presence in nutritional and chemical formulations.
Enzyme Activity Determination: Alpha-Ketoglutaric acid serves as a substrate for the determination of amino-converting enzymes and dehydrogenase. It is also used as a supporting reagent in liver function tests, helping to assess metabolic processes.
Sports Nutrition: A key ingredient in sports nutrition drinks, Alpha-Ketoglutaric acid supports enhanced physical performance by aiding in energy production and muscle recovery, making it an essential component for athletes.
Health and Medicine: Used as a raw material and food additive in the formulation of medicines and health products, it contributes to overall well-being by playing a vital role in metabolic processes and amino acid synthesis.
Analytical Applications: Employed as an analytical reagent for tryptophan, Alpha-Ketoglutaric acid is essential in enzyme activity studies. It is particularly valuable as a substrate for determining amino-converting enzyme and dehydrogenase levels in laboratory tests.
Organic Synthesis: As a derivative of valeric acid, Alpha-Ketoglutaric acid is a critical intermediate product in the Krebs cycle, catalyzed by glutamate dehydrogenase. This makes it an important building block in the synthesis of other organic compounds used in various industrial applications.
Environmental Impact: Handle with care to avoid contact with water, as it may be harmful to the environment.
Storage Conditions: Store between 2–8°C to maintain its quality and stability.
Safety Precautions: Follow standard laboratory and manufacturing safety guidelines when handling this compound.
What is Alpha-Ketoglutaric acid used for?
Alpha-Ketoglutaric acid is primarily used in sports nutrition, organic synthesis, and as a reagent in enzyme activity studies.
Is Alpha-Ketoglutaric acid soluble in water?
It is slightly soluble in water, allowing it to participate effectively in biological and metabolic processes.
How should Alpha-Ketoglutaric acid be stored?
It should be stored at temperatures between 2–8°C to ensure optimal quality.
What are the benefits of using Alpha-Ketoglutaric acid in sports nutrition?
It helps in enhancing energy production, supporting muscle recovery, and improving athletic performance.
Is Alpha-Ketoglutaric acid safe to use in food and health products?
Yes, when used within regulated guidelines, it is safe for inclusion in nutritional supplements and health products.
