Methyl Acetoacetate (MAA): A Versatile Intermediate in Organic Synthesis

Introduction

Methyl Acetoacetate (MAA), with the CAS number 105-45-3, is a pivotal compound in organic synthesis. This article explores its chemical profile, physical properties, applications, and storage considerations.

Chemical Profile

• Molecular Formula: C5H8O3

• Molar Mass: 116.12 g/mol

• Density: 1.076 g/mL at 25 °C (lit.)

• Melting Point: -80°C (lit.)

• Boiling Point: 169-170°C at 70 mmHg (lit.)

• Flash Point: 158°F

Physical Properties

Methyl Acetoacetate is a transparent liquid with high water solubility, reaching 460 g/L at 20°C. For optimal storage, it should be kept at 2-8°C in a cool, ventilated area with fire protection measures. It is commonly packaged in aluminum barrels with well-sealed lids to preserve stability.

Applications

Pesticides:

Intermediate Production:

Methyl Acetoacetate is used in synthesizing fungicides such as hymmezol, dimethylsulfurol, and ethylsulfurol, as well as insecticides like diazinon and pyrifos.

Pharmaceuticals:

Drug Production:

It is involved in the production of various drugs and pharmaceutical intermediates.

Organic Synthesis:

Solvent and Reagent:

Methyl Acetoacetate is used as a solvent for cellulose ether, a mixed solvent for cellulose resin, and in the synthesis of dyes and polymer stabilizers.

Conclusion

Methyl Acetoacetate (MAA) is a versatile and essential compound in the chemical industry. Its significant roles in pesticide synthesis, pharmaceutical production, and organic synthesis underline its importance as an intermediate in producing various chemical products.