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Pivaloylacetonitrile: A Key Intermediate in Organic Synthesis

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Pivaloylacetonitrile: A Key Intermediate in Organic Synthesis

Introduction:

Pivaloylacetonitrile(CAS numnber is 59997-51-2), a chemical compound with various synonyms including Cyanopinacolone and 4,4-Dimethyl-3-oxovaleronitrile, plays a significant role in organic synthesis. This article delves into its properties, applications, and storage requirements.

Properties:

  • Molecular Formula: C7H11NO

  • Molar Mass: 125.17 g/mol

  • Density: 1.0459 g/cm³ (rough estimate)

  • Melting Point: 66-69°C (lit.)

  • Boiling Point: 125-126°C at 22 mm Hg (lit.)

  • Flash Point: 59.5°C

  • Appearance: White to cream crystalline powder

  • Water Solubility: Insoluble in water

Applications:

  1. Organic Synthesis:

    • Intermediate for Pharmaceuticals: Pivaloylacetonitrile is utilized as a key intermediate in the synthesis of pharmaceuticals. It is notably used in the production of 1,1-dimethyl-3-uracil, which is a vital compound in medicinal chemistry.

    • Pesticide Production: It serves as an important intermediate in the synthesis of various pesticides, contributing to agricultural chemical formulations.

  2. Photosensitizers:

    • Film Photosensitizers: The compound is also a raw material for the preparation of film photosensitizers, which are used in photographic processes.

Storage and Handling:

  • Storage Conditions:

    Pivaloylacetonitrile should be stored in a dark place, sealed in a dry container, and kept at room temperature to maintain its stability.

  • Safety Measures:

    Ensure proper handling to avoid exposure, as it may pose risks in certain conditions. Follow standard safety protocols for handling chemicals, including using appropriate personal protective equipment (PPE).

Conclusion:

Pivaloylacetonitrile is a versatile compound with significant applications in pharmaceutical and agricultural industries. Its role as an intermediate in organic synthesis and its use in film photosensitizers underscore its importance in various chemical processes. Proper storage and handling are essential to preserve its integrity and ensure safe usage in industrial applications.


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