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Alverine Citrate CAS 5560-59-8

Appearance: neat
Color: White to Off-White
Storage Condition: 2-8°C
In vitro study:
Pharmacological studies have shown that Alverine citratehas has an effect on intestinal motility and intestinal sensitivity, and two factors have been found to be involved in the initiation of FBD, while no potential defects of systemic drugs have been found. Alverine citrate can affect basal and stimulating motility, this effect is achieved by calcium-dependent or independent inhibition of neuronal excitability and by direct inactivation of L-type calcium ions in smooth muscle cells. The experimental results support that the analgesic effect is exerted by a mechanism mediated by selective receptors.
Alverine citrate is suitable for various causes of gastrointestinal, intestinal functional disorders, and irritable bowel syndrome.
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Product Name Alverine Citrate
Synonyms alverine dihydrogen citrate; Alverine base or citrate; N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
Molecular Formula C26H35NO7
Molecular Weight 473.5586
CAS Registry Number 5560-59-8
Molecular Structure Alverine Citrate
Product Application It is a vital medication primarily utilized to treat ventricular arrhythmias and prevent heart attacks.


Chemical ldentity and Synonyms

Alverine Citrate, a medication recognized under various synonyms, 

such as CalMabel and AntispasMin, is identified by the CAS number 5560-59-8. 

It presents as a compound with the molecular formula C20H27N.C6H8O7, 

and a molar mass of 473.56 g/mol, manifesting as a neat, white to off-white substance. 

Functiona Appications

Primarily utilized in the treatment of ventricular arrhythmias and the prevention of heart attacks, 

Alverine Citrate operates as a highly selective calcium channel regulator. 

Its mechanism involves inhibiting the influx of excessive calcium ions into the smooth muscle cells of the intestinal wall, thereby mitigating intestinal peristalsis. 

This pharmacological action serves to alleviate symptoms associated with functional gastrointestinal diseases, including loose or frequent stools and abdominal pain stemming from intestinal spasms.

Chemical Properties

Alverine Citrate boasts a melting point of 100-102°C, a boiling point of 358.8°C at 760 mmHg, 

and a flash point of 174.4°C. Its efficacy in managing gastrointestinal discomfort symptoms, 

coupled with its role in cardiac care, renders it a pivotal therapeutic agent in contemporary medicine. 

Safety and Storage

The drug's favorable safety profile and stringent storage conditions further ensure its stability and efficacy for medical application,that warrants storage at cool temperatures ranging from 2 to 8°C.


Product Description:
Alverine citrate, the main component of citric acid alverine, is a highly selective calcium ion channel modulator that can effectively inhibit the excessive entry of calcium ions into the smooth muscle cells of the intestinal wall, thereby inhibiting intestinal motility, thereby improving symptoms of loose stools or frequent stools, and also relieving abdominal pain caused by intestinal spasms.


Indications:
Alverine citrate is suitable for various causes of stomach and intestinal functional disorders, and irritable bowel syndrome.

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