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N,N'-Dicyclohexylcarbodiimide CAS 538-75-0

dicyclohexylcarbodiimide (DCC) is also used for the synthesis and dehydration of amikacin and amino acids. it is a good low-temperature biochemical dehydrating agent and is also used for the synthesis of acids, anhydrides, aldehydes, ketones, etc. In Japan, dehydrating agents used for glutathione account for 90% of total consumption. When the product is used as a dehydration and condensing agent, it can be reacted in a short time at room temperature, and the product after the reaction is dicyclohexylurea.
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Product Name N,N'-Dicyclohexylcarbodiimide
Synonyms DCC; Dicyclohexyl CARBODIMIDE; Dicyclohexylcarbodiimide; N,N'-Dicyclohexyl carbodiimide; N,N'-Dicyclohexylcarbodimide; N,N'-diphenylcarbodiimide; N,N-dicyclohexylcarbodiimide; N,N-dicyclohexyl carbodiimide; N,N'-dicyclohexyl carbodimide
Molecular Formula C13H22N2
Molecular Weight 206.33
CAS Registry Number 538-75-0
Molecular Structure N,N-Dicyclohexylcarbodiimide
Product Application Used as a biochemical reagent and organic synthesis dehydrating condensing agent.


Names and Identifiers

N,N’-Dicyclohexylcarbodiimide (DCC) is a chemical compound,

with the CAS number 538-75-0 and the molecular formula C13H22N2. 

It has many synonyms, such as Dicyclohexyl CARBODIMIDE, N,N’-Dicyclohexylcarbodiimide [for Peptide Synthesis], and DCC Dicyclohexylcarbodiimide. 

Chemical Properties

It is a colorless or pale yellow liquid with a density of 1.247 g/mL, a melting point of 34-35°C, 

a boiling point of 122-124°C, and a flash point of 190°F. 

It is stable, non-flammable, and soluble in organic solvents, but it can polymerize and oxidize.

Production Usage

DCC is mainly used as a dehydration and condensation agent in organic synthesis and biochemical reactions. 

It is especially effective in the synthesis of peptides and nucleic acids, 

where it activates the carboxyl groups of amino acids and facilitates the formation of amide bonds. 

It is also used for the synthesis and dehydration of amikacin, a type of antibiotic, and amino acids. 

It can also synthesize acids, anhydrides, aldehydes, ketones, and other compounds. 

It is widely used in the production of pharmaceuticals, such as hypertensives and cyclic adenosine monophosphate.

Safety and Storage

DCC is a useful reagent for various industrial applications, but it requires proper handling and safety precautions. 

It has moderate toxicity and can irritate the respiratory tract, eyes, and skin. 

It should be used with protective gear, such as rubber gloves and goggles, and stored in a cool and dry place.


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